GLYCOGEN STORAGE DISEASES
Accumulation of fluid in the cavity of
causing impaired hear-
ing. Persistent glue ear is most common
in children. It is often accompanied by
and frequently occurs
with viral respiratory tract infections,
such as the common
It is usual for
both ears to be affected.
In glue ear, the lining of the middle
ear becomes overactive, producing large
amounts of a sticky fluid, and the
(w hich links the middle ear
to the back of the nose and throat)
drain away. The accumulated
fluid interferes with the movement of
the delicate bones of the middle ear.
Glue ear is sometimes first detected
Examination w ith an
confirm the diagnosis.
M ild cases of the condition often
clear up without specific treatment. If
symptoms persist, the insertion of
(small tubes) may be necessary,
w hich allows air into the middle ear
and encourages fluid to drain away.
(removal of the aden-
oids) may also be required.
Effects of glue ear
In this condition, sticky fluid in the middle ear
prevents free movement of the eardrum and
ossicles, causing deafness.
A topical (applied to the skin) prepara-
tion for the treatment of
may cause a rash or irritation and may
stain the skin brown.
A term meaning “relating to the but-
tocks” , as in the gluteal muscles.
A combination of gliadins and gluten-
ins (types of proteins) present in wheat,
rye, and barley. Mixed with water, flours
containing gluten become sticky and
trap air, thus forming dough. Sensitivity
to gluten causes
The large, powerful
in each of
rounded shape. The gluteus maximus is
responsible for moving the thigh side-
ways and backwards.
A colourless, syrupy liquid that has a
sweet taste. Glycerol is an essential con-
(simple fats) in
the body. It may also be prepared com-
fats and oils
added to moisturizing creams to help
prevent dryness and cracking of the
skin. It is also used in eardrops to help
soften earwax, and in
help soothe a dry, irritating cough. Fur-
thermore, glycerol is added to rectal
softening hard faeces.
used for the treatment
and prevention of symptoms of
(chest pain due to inadequate
blood supply to the heart).
sprays and tablets are available for
rapid pain relief and slow-release tablets
or skin patches for sustained pain relief.
The drug is sometimes prescribed to
treat anal fissures but is not licenced
for this use. High doses may cause
headaches, flushing, and dizziness.
The main form of
the body. Glycogen is a polysaccharide,
consisting of chains of
ecules, and is found mainly in the liver
and in muscles.
W hen there is excess glucose in the
blood, it is converted to glycogen by
the action of
W hen the blood glucose level is low,
glycogen is converted back to glucose
and released into the bloodstream.
glycogen storage diseases
A group of rare
terized by an absence or deficiency of
(proteins that act as
catalysts) responsible for the metabo-
These enzyme defects
may lead to abnormal concentrations of
glycogen in the tissues, insufficient
(a simple sugar) in the blood, or
the inability of the body to use glucose
as energy. Also known as glycogenoses
or GSDs, these diseases may affect the
liver, the muscles, or both.